Skin Concerns
· Lines & Wrinkles
· Firming
What You’ll See On The Ingredient List
Variations of acetyl hexapeptide, acetyl octapeptide, palmitoyl oligopeptide, palmitoyl tetrapeptide, palmitoyl hexapeptide or others.
Why Your Skin Needs It
Peptides are amino acids that help increase the production of natural collagen and elastin, which are essential building blocks for youthful-looking skin. Strengthening the skin’s dermal matrix helps smooth the look of lines and wrinkles and help skin look and feel firmer, more resilient, and taut.
The Clinique Expertise
Repairing the look of lines and wrinkles isn’t a task for just one miracle ingredient. For more optimal de-aging power, we combine peptides with other wonder workers. On the most-wanted list: Clinique Smart Custom-Repair Serum combines acetyl-hexapeptide-8 with whey protein, salicylic acid, hyaluronic acid and vitamin C to help visibly smooth, lift, and brighten skin.
What Our Scientist Says
“We are always researching peptide variations as we continue to innovate. They are vital to helping increase skin’s natural collagen and elastin production, which play a critical role in helping skin look smoother, less lined, and more lifted,” says Dr. Tom Mammone, Vice President, Skin Physiology and Pharmacology.
ingredient to know
Peptides
ingredient to know
Peptides
Overview
Top Sellers With Peptides
#skincare
“My skin is loving @Clinique Smart Clinical MD. The innovative all-in-one moisturiser rejuvenates, addresses fine lines and wrinkles, dullness and uneven skin tones. Pairing it with the Smart Serum has given my skin a definite boost!”
@mimigstyle
#skincare
“My skin is loving @Clinique Smart Clinical MD. The innovative all-in-one moisturiser rejuvenates, addresses fine lines and wrinkles, dullness and uneven skin tones. Pairing it with the Smart Serum has given my skin a definite boost!”
@mimigstyle
Peptides 101.
Peptides in skincare are the answer to anti-ageing. Peptides are essentially amino acids that help to stimulate your skin to make collagen. For skincare lovers, you’ll know that collagen is what creates smoother, firmer, and youthful skin. It’s no wonder it is such a crucial ingredient in so many anti-ageing skincare products, like our Smart SPF15 Custom-Repair Moisturizer.
With a highly hydrating formula, the moisturiser instantly reduces the appearance of fine lines and brightens the skin’s complexion. The key to younger-looking skin is a strong moisture barrier. That is precisely what peptides in skincare products help to build and maintain. Not only do they provide instant hydration, but they work to retain the moisture in the skin throughout the day, and repair any damage to your skin’s moisture barrier. If you’re into anti-ageing, discover even more skin firming products.
To really lock in the hydration and optimise its benefits, opt for a moisturiser with peptides. Our Smart Clinical Repair™ Wrinkle Correcting Rich Cream is a dense, luxurious moisturiser that injects moisture into the skin to nourish your skin barrier. The soft texture of the cream smooths the skin’s surface, creating youthful and bright-looking skin. Similar to any other moisturiser you might use, apply this as the last step to your skincare routine to seal in all your products.
More Key Ingredients
Aloe Bioferment + HA Complex
Aloe bioferment + HA complex helps hydrate in two ways—attracts moisture and helps retain it.
Alpha Hydroxy Acids
Alpha hydroxy acids gently slough away dead skin cells, revealing smoother and brighter skin.
CL302 Complex
Clinique’s exclusive CL302 Complex helps visibly reduce dark spots and discoloration.
Glycerin
Glycerin supports your skin’s natural moisture barrier by attracting moisture from the air and retaining water in skin to help keep the skin hydrated.
Gyokuro Green Tea
Gyokuro green tea has antioxidant and anti-inflammatory properties that help calm upset skin, reduce irritation, and protect against future damage.
Hyaluronic Acid
Hyaluronic acid plumps skin with hydration, helping it look and feel better instantly.
Lactobacillus Probiotic Ferment
Lactobacillus probiotic ferment helps calm the look of irritation and promotes stronger skin.
Retinoid
Retinoids are derived from vitamin A, which helps accelerate cell turnover and refine skin’s texture.
Safflower Seed
Safflower Seed Oil is rich in linoleic acid and helps leave skin feeling soft and nourished.
Sigesbeckia Orientalis Extract
Sigesbecia Extract is a powerful procollagen extract, prized for helping skin maintain its natural density.
The Clinique Formula:
Performance, Safety, Science
Clinique launched the first-ever line of dermatologist-developed skincare in 1968. The promise: to deliver effective, safe, clinically proven formulas that create great skin. We avoid using allergens, irritants and ingredients in ways that could potentially harm your skin.
Proven results are from how multiple ingredients are combined using the latest scientific breakthroughs to achieve maximum results without irritation. As science evolves, we continuously re-examine ingredients with our researchers, formulators, clinicians, and guiding board-certified dermatologists.
No parabens. No phthalates. No fragrance. Just happy skin.
Pro Vitamin-D
Frequently Asked QuestionsPro Vitamin D provides antioxidant protection to help defend skin from stressors and free radicals which can leave skin dehydrated and also lead to premature signs of aging. It also helps support ceramide production which supports sustained hydration.
By choosing formulas enriched with this ingredient, you’re boosting your skin’s environment-defense system.
Clinique incorporates Pro Vitamin D into select formulas to help bolster skin’s natural environmental stress-defense system and protect skin against daily dehydrators like pollution, blue light, and other environmental aggressors. Using a formula with Pro Vitamin D means you’re aligning with Clinique’s science-driven approach to strong skin resilience.
Treat a Pro Vitamin D-infused product just like you would any high-performance moisturizer or SPF step: cleanse your skin, apply your targeted treatments such as serum or eye treatment, then follow with the product containing Pro Vitamin D as your final step of that sequence morning and evening as directed.
Because Pro Vitamin D works to support environmental defense and hydration, using such a formula in the morning is particularly beneficial when your skin faces daily stressors.
Yes, you can. For example, you might use a serum targeting a specific concern such as uneven tone or fine lines and then apply one of the Clinique products above. Since Pro Vitamin D helps support your skin’s protective and hydrating functions, pairing it with your usual treatment steps makes sense. Follow the lightest-to-heaviest rule, applying serum before moisturizer or SPF, and ensure compatibility if you’re using exfoliants, retinoids, or strong actives.
Yes. Both of the Clinique products recommended above are described as allergy tested and safe for sensitive skin. For example, the Moisture Surge Broad Spectrum SPF 28 Sheer Hydrator is labeled dermatologist tested, safe for sensitive skin, and allergy tested.
No. While Pro Vitamin D supports your skin’s defense against environmental stressors and dehydration, it does not replace primary sun-protection measures in the morning such as a broad-spectrum SPF. If your Clinique product includes SPF, like the Clinique Moisture Surge Broad Spectrum SPF 28 Sheer Hydrator or Clinique Smart Clinical Repair Broad Spectrum SPF 30 Wrinkle Correcting Cream, it serves dual purposes of protection and moisture. If you use a formula without SPF, you still need to apply a dedicated sunscreen after.
Because Pro Vitamin D works on your skin’s protective and moisture-retention systems rather than quick surface changes, you can expect gradual improvement in how resilient and hydrated your skin looks and feels. Track your skin’s comfort, plumpness, and ability to resist environmental stress over two to four weeks and beyond.